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Preface
About the Companion Website

1. Cancer Epidemiology
2. Cancer Histopathology
3. Carcinogenesis
4. Molecular Biology of Cancer
5. Cancer Metastasis
6. Health Professionals and Cancer Treatment
7. Principles of Cancer Chemotherapy
8. Cytotoxic Compounds
9. Antimetabolites and Hormonal Blockers
10. Cancer Research
11. Clinical Trials
12. Tumor Hypoxia
13. Antiangiogenic and Antivascular Agents
14. Protein Kinase and Ras Blockers
15. Modulating Global Gene and Protein Expression
16. Stem Cells - Telomerase, Wnt, Hedgehog, Notch, and Galectins
17. Immunotherapy and Oncolytic Viruses
18. pharmaceutical Problems in Cancer Chemotherapy

Index

Provides a clear and accessible summary of all stages and aspects of the discovery, design, development, validation and clinical use of anticancer drugs

This new edition provides an update on the current state of cancer chemotherapy and clinical practice and presents new pipeline anticancer agents and promising therapeutic strategies that are emerging alongside new breakthroughs in cancer biology. Its unique approach enables students to gain an understanding of the pathological, physiological, and molecular processes governing malignancy, while also introducing the role of health professionals and scientists in the research and treatment of cancer.

Invaluable for its clarity and accessibility, Cancer Chemotherapy: Basic Science to the Clinic, Second Edition offers complete coverage of the scientific and clinical aspects of the creation, development, and administration of drugs or drug regimens used in the treatment of the disease. Chapters look at: cancer epidemiology and histopathology; carcinogenesis; current research; tumor hypoxia; antiangiogenic and antivascular agents; protein kinase and Ras blockers; new targets associated with development such as Hedgehog and Wnt signaling; stem cells; immunotherapy and oncolytic viruses; and more.

Presents a clear, accessible, and comprehensive approach to cancer chemotherapy from basic science to clinical practice
Offers a major update that reflects the latest developments in personalized chemotherapy
Provides in-depth coverage of advances in biomarker diagnostics
Includes new chapters/sections on bioinformatics and the 'omic sciences'; pharmaceutical strategies used to achieve tumor-selective drug delivery; and cancer cell autophagy
Combines descriptions of both clinical protocol and explanations of the drug design process in one self-contained book
Features numerous diagrams and illustrations to enhance reader understanding
Aimed at upper undergraduate, graduate, and medical students, Cancer Chemotherapy: Basic Science to the Clinic, Second Edition is also an excellent reference for health professionals, especially clinicians specializing in Clinical Oncology, and their patients who want to gain an understanding of cancer and available treatment options.

Provides a clear and accessible summary of all stages and aspects of the discovery, design, development, validation and clinical use of anticancer drugs This new edition provides an update on the current state of the art of cancer chemotherapy and clinical practice and presents new pipeline anticancer agents and promising therapeutic strategies that are emerging alongside new breakthroughs in cancer biology. Its unique approach enables students to gain an understanding of the pathological, physiological, and molecular processes governing malignancy, while also introducing the role of health professionals and scientists in the research and treatment of cancer. Invaluable for its clarity and accessibility, Cancer Chemotherapy: Basic Science to the Clinic, 2nd Edition offers complete coverage of the scientific and clinical aspects of the creation, development, and administration of drugs or drug regimens used in the treatment of the disease. Chapters look at: cancer epidemiology and histopathology; carcinogenesis; current research; tumor hypoxia; antiangiogenic and antivascular agents; protein kinase and Ras blockers; new targets associated with development such as Hedgehog and Wnt signaling; stem cells; immunotherapy and oncolytic viruses; and more. Presents a clear, accessible, and comprehensive approach to cancer chemotherapy from basic science to clinical practice Offers a major update that reflects the latest developments in personalized chemotherapy Provides in-depth coverage of advances in biomarker diagnostics Includes new chapters/sections on bioinformatics and the 'omic sciences'; pharmaceutical strategies used to achieve tumor-selective drug delivery; and cancer cell autophagy Combines descriptions of both clinical protocol and explanations of the drug design process in one self-contained book Features numerous diagrams and illustrations to enhance reader understanding Aimed at upper undergraduate, graduate, and medical students, Cancer Chemotherapy: Basic Science to the Clinic, 2nd Edition is also an excellent reference for health professional, especially clinicians specializing in Clinical Oncology, and their patients who want to gain an understanding of cancer and available treatment options.