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This is a clear, up-to-date and authoritative account of the principles that govern the way proteins work. The book provides advanced undergraduate students in biochemistry and biophysics in vivo context for the standard protein sequence-structure-function model.
Mike Williamsondid his PhD and subsequent research at the University of Cambridge before moving to the lab of Nobel Laureate Kurt W?hrich in Switzerland. There he worked on the first NMR structure of a globular protein. He is a professor of Biochemistry at the University of Sheffield.
High-throughput omics " projects such as genome sequencing, structural genomics and proteomics mean that there is no shortage of information on proteins. But the more information we have, the harder it is to make sense of it, to know where to start, and to identify the important results. This book is a clear, up to date and authoritative account of the principles that govern the way proteins work, and sets proteins within the context in which they function: within the cell, within biological systems, and within the limitations fixed by physics, chemistry, and evolution, taking examples from many different areas of biology. It provides an integrated view of proteins, showing how evolutionary pressure has driven proteins to adopt a domain structure, and to put these domains together in various combinations in order to achieve a biological outcome. It shows how the association of proteins into dimers, complexes (molecular machines) and multi-enzyme complexes allows them to achieve remarkable catalytic and functional efficiency. It shows how evolution has led to an accumulation of regulatory and scaffold proteins, particularly with reference to signaling pathways; and it presents current views of protein dynamics and interactions. For the student it provides a framework, showing where old and new results fit in, and for the postgraduate and researcher it provides an up to date and coherent account of the relationship between protein function, structure and dynamics.
How Proteins Workis a clear, up-to-date and authoritative account of the principles that govern the way proteins work. This book will provide advanced undergraduate students in biochemistry and biophysics in vivo context for the standard protein sequence-structure-function model. The text will also serve as a valuable resource for graduate students and researchers looking for a reference on the fundamentals underlying protein function.
How Proteins Workis an up-to-date and authoritative account of protein function in living systems, explained within the governing parameters of physics, chemistry, and evolution. This text will enable advanced undergraduate students in biochemistry and biophysics to understand the relationships among protein function, structure, and dynamics. It will also serve as a valuable resource for graduate students and researchers looking for a reference on the fundamentals underlying protein function. By providing an integrated view of proteins at both a cellular and systemic level, this textbook shows how evolution drives proteins to adopt domain structures that combine to achieve biological outcomes. The association of proteins into dimers, molecular machines, and multi-enzymatic complexes enables them to achieve catalytic and functional efficiency.
"I think this is a really nice book that offers an alternative perspective on protein structure and function for biochemistry students..." Timothy Bugg, Chemistry World