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Preface
Acknowledgements
Abbreviations recurrently used
1 Cytokines: a world apart? 1
Pt. I Pharmacology
2 Inhibitors of cytokine production and action 21
3 Inhibitors of cytokine processing 84
4 Interleukin-1 receptor antagonist 91
5 Antibodies and soluble receptors 120
6 Anti-inflammatory and immunosupressive cytokines 142
7 Pharmacology of chemokines 154
Pt. II Pharmacology in a context
8 Nervous system 185
9 Cardiovascular system 194
10 Cancer 224
11 Liver and lung 245
12 Skin 255
13 Septic shock 266
App Mechanisms of action and clinical uses of Type I interferons 279
Index 319
Ã¥¼Ò°³
Pharmacology of Cytokines overviews the field of cytokine research and describes the various approaches that have been taken to develop the pharmacology of these novel mediators. Within the framework of the immunobiology of cytokines, this book examines the interactions with the cytokine system of a variety of compounds ranging from simple synthetic chemicals to biotechnological products. In addition to examining individual agents and approaches, the book examines the pathophysiology of individual body systems and analyses specific contexts for the pathophysiology of these mediators as well as pharmacological approaches for their control.
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